Depends on what kind of music you play. While they take much longer to tune, they are awesome for incredible hardcore bends and dives for heavy lead in hard rock. While dimebag was amazing and could probably play a broomstick with dental floss, Pantera wouldn't have had even close to the same sound without it, nor would Van Halen. Imagine trying to play eruption on a fender strat, it would be completely impossible, you would be so out of tune you wouldn't be able to tell wtf you were trying to play. They actually stay in tune better once you stretch out the strings, so they have their place. Blues is super fun on them as well, because you can push down on the bridge to bend up quite a bit too so you can do super high bends that are almost impossible to do otherwise. They also make drop tuning levers for them, so you can instantly change tunings for different stuff too.
I have several guitars, most are old school but i have an American made Jackson, complete with custom pickups and active sustainic electronics. I'm not good enough to even come close to doing all the cool stuff it can do.