Nothing is perfect, best is at least 2 to get what the other doesn't. If having to reinstall because of virus, it is best to wipe out all partitions, and slow format. A virus can hyde in a restore or diagnostic disk partition and reinfect after re-installation into the os(operating system) partition. Sometimes a quick format isn't 'deep' enough.
Another point is to always update virus definitions before scanning. Don't run 2 antivirus at once (turn one off, but can run 2 anti spyware etc. just not 2 firewalls or anti virus at same time) for they can set each other off, or even crash sys if both scan (anti-virus) the same file at the same time.
http://www.threatfire.com/ is different,it is antiviral and can be run/is maid to run with av ware. It doesn't work on definitions so much, as behavior. So, can spot stuff that there isn't a definition for yet. To get a virus definition, so many people have to get infected, that are served by a company, that the virus is realized, defined, and deemed worth the time by the damage, speed and saturation they threaten, then a definition is written, then dispersed. Then the bad guy sees that, and tweaks his end a bit, and the cycle repeats. So av ware that can track virus by behavior before a threat is defined is good. So, things will get worse; the best protection choice may change. AVG is good, but is not as hailed for treating today's issues, as much as it was for yesterday's.
It can be really something to be running tcpview and see a bunch of connections hit a box when there is no internet window open etc. If you get familiar with it, process explorer and autoruns, you can pick stuff out that is suspicious and shut it down, research etc. It is best to do occasionally and become familiar before having problem of curse, but; that isn't when most of us start... Really want a lesson, take a sys that you are going to reimage/re-install and run process explorer and auoruns before and after; then try not to let the before happen again, by keeping it all skinnied down to look like the after (re-imaging).
A common statistic is that if you put an unprotected box on the internet, it is attacked in 15 minutes; some even say 'owned' in that amount of time. Some of the latest stuff is passed around by thumb drives though, just like it used to be on floppies before the internet.