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When you apply something like roundup, you need to apply it as quickly as possible. When it fails, its quite often from waiting too long.

I trace the cambium and apply Roundup. We killed a eucalyptus a roadway away once by doing that so I don't use it on trees I suspect of being grafted like poplars. I wonder if you kill a broadleaf tree right after it leaves out in spring if it has much energy left to root sprout?